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with significant suppression of tumor growth upon daily oral dosing at 10 and 30 mg/kg (%T/C = 68% and 20%
11(11):2499-507
ClH/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19
2017 May 1
Thalidomide-Propargyne-PEG2-COOH lafenamide hemifumarate with significant suppression of tumorThalidomide Propargyne PEG2 COOH is a synthesized E3 ligase ligand linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Product information Molecular Weight: 428. 39 Formula: C21H20N2O8 Chemical Name: 3 [2 ({3 [2 (2, 6 dioxopiperidin 3 yl) 1, 3 dioxo 2, 3 dihydro 1H isoindol 5 yl]prop 2 yn 1 yl}oxy)ethoxy]propanoic acid Smiles: OC(=O)CCOCCOCC#CC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O
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